Pterostilbene vs Shilajit (Purified)

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

PterostilbeneShilajit (Purified)
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerateModerate
A

Pterostilbene

Supplements

Mechanism

Dimethylated analog of resveratrol with 4x greater oral bioavailability. Activates SIRT1 and AMPK, reduces oxidative stress, and improves lipid profiles. Superior pharmacokinetics compared to resveratrol due to methyl groups protecting against glucuronidation.

Contraindications

  • Hormone-sensitive conditions (mild estrogenic activity)

Mechanism

Fulvic acid-rich mineral complex that enhances mitochondrial CoQ10 function, increases testosterone (via FSH), and acts as a potent electron carrier in the ETC. Enhances bioavailability of other supplements. Contains dibenzo-alpha-pyrones and fulvic acids.

Contraindications

  • Hemochromatosis
  • Must use purified form — raw shilajit may contain heavy metals

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