Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| MGF (Mechano Growth Factor) | PEG-MGF | |
|---|---|---|
| Category | Growth Factors | Growth Factors |
| Standard Dose | Research indicates 100-200 mcg per injection site, administered bilaterally into target muscles immediately post-workout. | — |
| Timing | Immediately post-workout (within 5-10 minutes) for optimal satellite cell activation. Must be injected directly into the trained muscle. | — |
| Cycle Duration | 4-6 week cycles. | — |
| Evidence Level | animal_plus_anecdotal | Preclinical |
MGF is the E domain peptide of the IGF-1Ec splice variant, produced when the IGF-1 gene is mechanically spliced in response to muscle damage or exercise. It activates satellite cells (muscle stem cells), promoting their proliferation and preventing premature differentiation. After exercise/injury, IGF-1 gene is first spliced toward MGF (proliferation phase) then shifts to IGF-1Ea (differentiation phase). MGF uniquely drives the initial proliferative response, expanding the pool of myogenic precursor cells before they fuse with existing muscle fibers.
Research indicates 100-200 mcg per injection site, administered bilaterally into target muscles immediately post-workout.
Immediately post-workout (within 5-10 minutes) for optimal satellite cell activation. Must be injected directly into the trained muscle.
4-6 week cycles.
Pegylated mechano growth factor analog discussed in muscle repair and hypertrophy contexts with limited human evidence.
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