Growth Factors
Evidence: animal_plus_anecdotal
MGF is the E domain peptide of the IGF-1Ec splice variant, produced when the IGF-1 gene is mechanically spliced in response to muscle damage or exercise. It activates satellite cells (muscle stem cells), promoting their proliferation and preventing premature differentiation. After exercise/injury, IGF-1 gene is first spliced toward MGF (proliferation phase) then shifts to IGF-1Ea (differentiation phase). MGF uniquely drives the initial proliferative response, expanding the pool of myogenic precursor cells before they fuse with existing muscle fibers.
Standard: Research indicates 100-200 mcg per injection site, administered bilaterally into target muscles immediately post-workout.
Maintenance: Research indicates 100 mcg per muscle group 2-3 times per week.
Administration: intramuscular
Timing: Immediately post-workout (within 5-10 minutes) for optimal satellite cell activation. Must be injected directly into the trained muscle.
Duration: 4-6 week cycles.
Native MGF has an extremely short half-life (5-7 minutes), requiring immediate post-workout injection directly into trained muscles. This impracticality led to the development of PEG-MGF. MGF is for advanced users who can manage precise timing. The research showing IGF-1 gene splicing first toward MGF then toward IGF-1Ea after exercise provides the scientific rationale for timing protocols. MGF is best understood as the body's initial muscle repair signal — expanding the satellite cell pool that will later differentiate under IGF-1Ea influence.
Research-grade supplier. Very short half-life (5-7 minutes) makes sourcing and timing critical. Store at -20C.
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