Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| AOD-9604 | MGF (Mechano Growth Factor) | |
|---|---|---|
| Category | Growth Factors | Growth Factors |
| Standard Dose | Research indicates 250-300 mcg daily via subcutaneous injection, administered in the morning on an empty stomach. | Research indicates 100-200 mcg per injection site, administered bilaterally into target muscles immediately post-workout. |
| Timing | Morning administration on empty stomach, at least 30 minutes before eating. Fasted state enhances lipolytic effect. | Immediately post-workout (within 5-10 minutes) for optimal satellite cell activation. Must be injected directly into the trained muscle. |
| Cycle Duration | 12-20 week cycles. | 4-6 week cycles. |
| Evidence Level | moderate_human | animal_plus_anecdotal |
AOD-9604 is a synthetic 16-amino acid fragment (residues 176-191) of the C-terminal domain of human growth hormone with a tyrosine substitution at the N-terminus. It selectively stimulates lipolysis by upregulating beta-3 adrenergic receptors in adipose tissue while inhibiting lipogenesis. It modulates lipid and glucose metabolism through beta-adrenergic and AMPK-related pathways without influencing IGF-1 activity, growth, or insulin sensitivity — retaining GH's fat-burning properties without its growth-promoting effects.
Research indicates 250-300 mcg daily via subcutaneous injection, administered in the morning on an empty stomach.
Morning administration on empty stomach, at least 30 minutes before eating. Fasted state enhances lipolytic effect.
12-20 week cycles.
MGF is the E domain peptide of the IGF-1Ec splice variant, produced when the IGF-1 gene is mechanically spliced in response to muscle damage or exercise. It activates satellite cells (muscle stem cells), promoting their proliferation and preventing premature differentiation. After exercise/injury, IGF-1 gene is first spliced toward MGF (proliferation phase) then shifts to IGF-1Ea (differentiation phase). MGF uniquely drives the initial proliferative response, expanding the pool of myogenic precursor cells before they fuse with existing muscle fibers.
Research indicates 100-200 mcg per injection site, administered bilaterally into target muscles immediately post-workout.
Immediately post-workout (within 5-10 minutes) for optimal satellite cell activation. Must be injected directly into the trained muscle.
4-6 week cycles.
Take our free assessment to get personalized recommendations based on your health goals, current stack, and biomarkers.
Get Your Free Protocol →or take the assessment →