Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Glucoraphanin (Broccoli Seed Extract) | Nattokinase | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | 2000-4000 FU (fibrinolytic units) daily, equivalent to 100-200mg |
| Timing | — | On empty stomach, between meals or before bed. Morning and evening split dosing for 24-hour fibrinolytic coverage. |
| Cycle Duration | — | ongoing |
| Evidence Level | Moderate-Strong | moderate_human |
Stable precursor to sulforaphane. Requires myrosinase enzyme (from gut bacteria or co-administered) for conversion. Provides sustained sulforaphane release compared to direct supplementation. Activates Nrf2 pathway for antioxidant and detoxification gene expression.
Nattokinase is a fibrinolytic serine protease extracted from natto (fermented soybeans). It directly degrades fibrin (the structural protein of blood clots) through four mechanisms: direct fibrinolysis, enhancement of endogenous tPA (tissue plasminogen activator) production, conversion of prourokinase to urokinase, and degradation of PAI-1 (plasminogen activator inhibitor-1). It also reduces blood viscosity and may inhibit ACE (angiotensin-converting enzyme), providing mild antihypertensive effects.
2000-4000 FU (fibrinolytic units) daily, equivalent to 100-200mg
On empty stomach, between meals or before bed. Morning and evening split dosing for 24-hour fibrinolytic coverage.
ongoing
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