Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Benfotiamine | Nattokinase | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | 2000-4000 FU (fibrinolytic units) daily, equivalent to 100-200mg |
| Timing | — | On empty stomach, between meals or before bed. Morning and evening split dosing for 24-hour fibrinolytic coverage. |
| Cycle Duration | — | ongoing |
| Evidence Level | Moderate | moderate_human |
Lipid-soluble thiamine derivative that improves cellular thiamine availability and helps reduce advanced glycation stress in high-glucose environments.
Nattokinase is a fibrinolytic serine protease extracted from natto (fermented soybeans). It directly degrades fibrin (the structural protein of blood clots) through four mechanisms: direct fibrinolysis, enhancement of endogenous tPA (tissue plasminogen activator) production, conversion of prourokinase to urokinase, and degradation of PAI-1 (plasminogen activator inhibitor-1). It also reduces blood viscosity and may inhibit ACE (angiotensin-converting enzyme), providing mild antihypertensive effects.
2000-4000 FU (fibrinolytic units) daily, equivalent to 100-200mg
On empty stomach, between meals or before bed. Morning and evening split dosing for 24-hour fibrinolytic coverage.
ongoing
Take our free assessment to get personalized recommendations based on your health goals, current stack, and biomarkers.
Get Your Free Protocol →or take the assessment →