Digestive Enzymes (Broad Spectrum) vs Sulforaphane (from Broccoli Sprout Extract)

Mechanism

Broad-spectrum digestive enzyme complexes supplement endogenous pancreatic and brush border enzyme production. Key enzymes include: lipase (triglyceride hydrolysis to fatty acids/glycerol), protease/peptidase (protein to amino acids via peptide bond cleavage), amylase (starch to maltose/glucose), lactase (lactose to glucose/galactose), cellulase (plant fiber breakdown), and invertase (sucrose hydrolysis). They reduce osmotic load in the small intestine, decrease bacterial fermentation of undigested substrate, and improve nutrient bioavailability.

Standard Dosing

1-2 capsules with each main meal

Timing

Immediately before or at the start of each meal. Not needed for small snacks.

Cycle Duration

ongoing as needed

Side Effects

• GI cramping if taken without food
• Allergic reactions (rare)
• Mouth ulcers from chewing enzyme capsules
• Perianal irritation from lipase at very high doses

Contraindications

• Acute pancreatitis
• Known allergy to enzyme sources (porcine, fungal, fruit-derived)

Best Stacking Partners

Mechanism

Isothiocyanate that activates Nrf2 — the master regulator of antioxidant defense. Upregulates glutathione synthesis, phase II detoxification enzymes, and heat shock proteins. Also inhibits HDAC (epigenetic modifier) and NF-kB (anti-inflammatory).

Contraindications

• Thyroid conditions (goitrogen at very high doses)
• Cruciferous vegetable allergy