Apigenin vs Digestive Enzymes (Broad Spectrum)

Mechanism

Flavonoid (found in chamomile, parsley) that inhibits CD38, the primary NAD+-consuming enzyme. Also a potent aromatase inhibitor and anxiolytic via GABA-A modulation. Supports NAD+ levels, reduces estrogen conversion, and improves sleep quality.

Contraindications

• Caution in pregnancy (uterotonic potential at high doses)

Mechanism

Broad-spectrum digestive enzyme complexes supplement endogenous pancreatic and brush border enzyme production. Key enzymes include: lipase (triglyceride hydrolysis to fatty acids/glycerol), protease/peptidase (protein to amino acids via peptide bond cleavage), amylase (starch to maltose/glucose), lactase (lactose to glucose/galactose), cellulase (plant fiber breakdown), and invertase (sucrose hydrolysis). They reduce osmotic load in the small intestine, decrease bacterial fermentation of undigested substrate, and improve nutrient bioavailability.

Standard Dosing

1-2 capsules with each main meal

Timing

Immediately before or at the start of each meal. Not needed for small snacks.

Cycle Duration

ongoing as needed

Side Effects

• GI cramping if taken without food
• Allergic reactions (rare)
• Mouth ulcers from chewing enzyme capsules
• Perianal irritation from lipase at very high doses

Contraindications

• Acute pancreatitis
• Known allergy to enzyme sources (porcine, fungal, fruit-derived)

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