Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Calcium Alpha-Ketoglutarate (Ca-AKG) | Nattokinase | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | 2000-4000 FU (fibrinolytic units) daily, equivalent to 100-200mg |
| Timing | — | On empty stomach, between meals or before bed. Morning and evening split dosing for 24-hour fibrinolytic coverage. |
| Cycle Duration | — | ongoing |
| Evidence Level | Moderate (healthspan), Emerging (human longevity) | moderate_human |
AKG is a TCA cycle intermediate that declines with age. Supplementation reduces inflammatory cytokines, improves stem cell function, and extends healthspan in mice. Calcium salt form provides sustained release. Also supports collagen synthesis and reduces frailty markers.
Nattokinase is a fibrinolytic serine protease extracted from natto (fermented soybeans). It directly degrades fibrin (the structural protein of blood clots) through four mechanisms: direct fibrinolysis, enhancement of endogenous tPA (tissue plasminogen activator) production, conversion of prourokinase to urokinase, and degradation of PAI-1 (plasminogen activator inhibitor-1). It also reduces blood viscosity and may inhibit ACE (angiotensin-converting enzyme), providing mild antihypertensive effects.
2000-4000 FU (fibrinolytic units) daily, equivalent to 100-200mg
On empty stomach, between meals or before bed. Morning and evening split dosing for 24-hour fibrinolytic coverage.
ongoing
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