Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Benfotiamine | Calcium Alpha-Ketoglutarate (Ca-AKG) | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | — |
| Timing | — | — |
| Cycle Duration | — | — |
| Evidence Level | Moderate | Moderate (healthspan), Emerging (human longevity) |
Lipid-soluble thiamine derivative that improves cellular thiamine availability and helps reduce advanced glycation stress in high-glucose environments.
AKG is a TCA cycle intermediate that declines with age. Supplementation reduces inflammatory cytokines, improves stem cell function, and extends healthspan in mice. Calcium salt form provides sustained release. Also supports collagen synthesis and reduces frailty markers.
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