Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| AOD-9604 | PEG-MGF (Pegylated Mechano Growth Factor) | |
|---|---|---|
| Category | Growth Factors | Growth Factors |
| Standard Dose | Research indicates 250-300 mcg daily via subcutaneous injection, administered in the morning on an empty stomach. | Research indicates 200-500 mcg administered 2-3 times per week via subcutaneous or intramuscular injection. |
| Timing | Morning administration on empty stomach, at least 30 minutes before eating. Fasted state enhances lipolytic effect. | On non-training days or several hours post-workout (to avoid competing with natural MGF pulse). Unlike native MGF, timing is more flexible due to extended half-life. |
| Cycle Duration | 12-20 week cycles. | 4-8 week cycles. |
| Evidence Level | moderate_human | animal_plus_anecdotal |
AOD-9604 is a synthetic 16-amino acid fragment (residues 176-191) of the C-terminal domain of human growth hormone with a tyrosine substitution at the N-terminus. It selectively stimulates lipolysis by upregulating beta-3 adrenergic receptors in adipose tissue while inhibiting lipogenesis. It modulates lipid and glucose metabolism through beta-adrenergic and AMPK-related pathways without influencing IGF-1 activity, growth, or insulin sensitivity — retaining GH's fat-burning properties without its growth-promoting effects.
Research indicates 250-300 mcg daily via subcutaneous injection, administered in the morning on an empty stomach.
Morning administration on empty stomach, at least 30 minutes before eating. Fasted state enhances lipolytic effect.
12-20 week cycles.
PEG-MGF is the pegylated form of Mechano Growth Factor, where polyethylene glycol (PEG) molecules are covalently attached to protect against rapid enzymatic breakdown. This extends the half-life from 5-7 minutes (native MGF) to approximately 48-72 hours. Like native MGF, it activates satellite cell proliferation, promotes muscle fiber regeneration and hypertrophy, and supports tissue repair. The extended half-life allows for systemic distribution rather than purely local action, enabling subcutaneous rather than intramuscular administration.
Research indicates 200-500 mcg administered 2-3 times per week via subcutaneous or intramuscular injection.
On non-training days or several hours post-workout (to avoid competing with natural MGF pulse). Unlike native MGF, timing is more flexible due to extended half-life.
4-8 week cycles.
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