Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Alpha Lipoic Acid (ALA) | Astragalus (Astragalus membranaceus) | |
|---|---|---|
| Category | Supplements | Adaptogens |
| Standard Dose | 300-600mg R-ALA daily | — |
| Timing | On empty stomach, 30-60 min before meals. Split doses for higher amounts. | — |
| Cycle Duration | ongoing or cycle 12 weeks on, 4 weeks off | — |
| Evidence Level | strong_human | Moderate |
ALA is a dithiol compound that functions as a cofactor for mitochondrial alpha-keto acid dehydrogenases (pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase). Both ALA and its reduced form DHLA are potent antioxidants capable of regenerating other antioxidants including vitamin C, vitamin E, and glutathione. ALA activates AMPK, improving glucose uptake via GLUT4 translocation, and modulates NF-kB-mediated inflammatory signaling. It chelates redox-active metals (Fe2+, Cu2+).
300-600mg R-ALA daily
On empty stomach, 30-60 min before meals. Split doses for higher amounts.
ongoing or cycle 12 weeks on, 4 weeks off
Contains cycloastragenol and astragaloside IV which activate telomerase (hTERT). Adaptogenic — modulates immune function, reduces inflammation, and supports cardiovascular health. Used in traditional Chinese medicine for Qi tonification.
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