Astragalus (Astragalus membranaceus) vs Maca Root (Gelatinized)

Mechanism

Contains cycloastragenol and astragaloside IV which activate telomerase (hTERT). Adaptogenic — modulates immune function, reduces inflammation, and supports cardiovascular health. Used in traditional Chinese medicine for Qi tonification.

Contraindications

• Autoimmune conditions
• Active cancer (telomerase activation concern)

Mechanism

Maca (Lepidium meyenii) contains unique macamides and macaenes (fatty acid derivatives), glucosinolates, and alkaloids. Unlike most adaptogens, maca does not directly affect testosterone, estrogen, or cortisol levels in blood. Instead, it appears to work as a 'hormonal normalizer' by acting on the hypothalamic-pituitary axis, modulating GnRH pulsatility and improving receptor sensitivity. Macamides interact with the endocannabinoid system (FAAH inhibition) and may modulate GABA and opioid pathways. Maca improves sexual function and desire through mechanisms independent of direct hormone elevation — likely central nervous system pathways.

Standard Dosing

1500-3000mg gelatinized maca daily

Timing

Morning with breakfast. Can be added to smoothies.

Cycle Duration

Cycle 12 weeks on, 4 weeks off, or ongoing

Side Effects

• GI upset/bloating (raw maca — gelatinized is much better tolerated)
• Insomnia
• Mood changes
• Increased heart rate (rare)
• Hormonal acne (rare)

Contraindications

• Hormone-sensitive cancers (glucosinolate metabolites may have hormonal effects)
• Severe hypothyroidism (goitrogenic potential)

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