Supplements

Alpha Lipoic Acid (ALA)

Evidence: strong_human

Mechanism of Action

ALA is a dithiol compound that functions as a cofactor for mitochondrial alpha-keto acid dehydrogenases (pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase). Both ALA and its reduced form DHLA are potent antioxidants capable of regenerating other antioxidants including vitamin C, vitamin E, and glutathione. ALA activates AMPK, improving glucose uptake via GLUT4 translocation, and modulates NF-kB-mediated inflammatory signaling. It chelates redox-active metals (Fe2+, Cu2+).

Dosing Protocol

Standard: 300-600mg R-ALA daily

Loading: 600-1200mg/day for neuropathy or metabolic support

Maintenance: 300mg/day R-ALA

Administration: oral

Timing: On empty stomach, 30-60 min before meals. Split doses for higher amounts.

Duration: ongoing or cycle 12 weeks on, 4 weeks off

Notes

Must supplement with biotin during prolonged use as ALA competes with biotin for transport. R-ALA is the natural form; racemic mixtures are cheaper but less effective per mg. Strong evidence for diabetic neuropathy (NATHAN, SYDNEY trials). Potent heavy metal chelator — use with caution in those with mercury amalgams.

Stacking

  • NAC
  • CoQ10
  • Acetyl-L-Carnitine
  • Biotin
  • Chromium

Interactions

  • Insulin/oral hypoglycemics [HIGH] — ALA enhances insulin sensitivity; may cause hypoglycemia. Monitor blood glucose.
  • Thyroid medications (levothyroxine) [MEDIUM] — ALA may reduce conversion of T4 to T3. Separate dosing by 4 hours.
  • Chemotherapy (cisplatin) [MEDIUM] — Theoretical reduction of oxidative anti-tumor mechanisms

Contraindications

  • Thiamine (B1) deficiency (ALA increases thiamine demand)
  • Hypoglycemia-prone individuals without monitoring
  • Autoimmune thyroid conditions (monitor thyroid function)

Side Effects

  • GI upset/nausea
  • Skin rash
  • Hypoglycemia symptoms
  • Body odor changes

Key Papers

  • 10.1016/j.freeradbiomed.2011.04.004
  • 10.2337/dc06-1216
  • 10.1016/j.pharmthera.2017.12.010

Source Quality

R-alpha lipoic acid (R-ALA) is the bioactive enantiomer — 2x more potent than racemic R/S-ALA. Stabilized R-ALA (Na-R-ALA or Bio-Enhanced R-ALA) preferred for stability. Brands: Doctor's Best (stabilized), Geronova Research.

Disclaimer: This information is for educational purposes only and is not medical advice. BioAccelera Labs does not diagnose, treat, or prescribe. Consult a licensed healthcare provider before using any compound.

Should Alpha Lipoic Acid (ALA) Be in Your Stack?

Take the free assessment and get personalized recommendations based on your biology and goals.

Get Your Free Protocolor take the assessment →
← Browse All 231 Compounds