Evidence-Based Compounds for Extending Healthspan
Longevity science has exploded in the last decade — from Sinclair's NAD+ work to the TAME trial for metformin. But separating signal from noise is critical. Most anti-aging supplements are selling hope, not evidence. Here are the compounds with real mechanistic rationale and clinical data.
Top Compounds
The BioAccelera Longevity Stack
⏰ Morning with breakfast (fat-containing)
- NMN 500mg-1g daily (sublingual preferred)
- CoQ10 (ubiquinol) 200mg daily
- Vitamin D3 5000 IU + K2 MK-7 200mcg
- Resveratrol 500mg-1g with fat (activates SIRT1)
- Berberine 500mg with meals (AMPK activation)
- Spermidine 1mg daily (autophagy inducer)
💡 The longevity field moves fast. NMN vs NR debate continues — NMN has more recent human trial data. Resveratrol bioavailability is poor; take with fat. Berberine and metformin may blunt exercise adaptations — don't take them around workouts.
Frequently Asked Questions
Does NMN actually work?
Human trials are promising but still early. The NAD+ precursor rationale is solid (NAD+ declines 50% by age 50), and animal data is strong. Several human RCTs show improved muscle function, insulin sensitivity, and NAD+ levels. Not definitive yet, but the mechanistic case is compelling.
Should I take metformin for longevity?
The TAME trial will answer this definitively. Current evidence: metformin extends lifespan in diabetics but may blunt exercise-induced mitochondrial adaptations. If you exercise seriously, berberine (similar AMPK activation, less exercise interference) may be the better choice. Talk to your doctor either way — it's prescription-only.
What about rapamycin?
Rapamycin (mTOR inhibitor) has the strongest animal longevity data of any compound. But immunosuppression is a real concern. Intermittent/pulsed dosing protocols are being explored. This is firmly in 'work with a longevity physician' territory — not something to self-administer.
How do I know if these are working?
Track biological age markers: DNA methylation tests (TruAge, GrimAge), blood biomarkers (hsCRP, glucose, lipids, IGF-1), and functional metrics (grip strength, VO2 max, HRV). Run panels every 6-12 months and track trends.
Get a Personalized Longevity & Anti-Aging Protocol
These are general recommendations. Your optimal protocol depends on your genetics, bloodwork, current stack, and health history. Let our AI build one specifically for you.