Evidence-Based Compounds for Maximizing Hypertrophy
Most muscle-building supplements are garbage. The ones that actually work have decades of research behind them. Here's what the evidence actually says — no hype, no sponsored recommendations, just compounds that move the needle on hypertrophy.
Top Compounds
The BioAccelera Hypertrophy Stack
⏰ Split between pre-workout and daily
- Creatine monohydrate 5g daily (no loading needed)
- L-Citrulline 6-8g pre-workout
- Beta-Alanine 3.2g daily
- HMB 3g daily (split doses)
- Ashwagandha KSM-66 600mg daily
💡 Creatine is the single most researched and effective supplement for muscle growth. Period. If you're only taking one thing, make it creatine monohydrate. Skip the fancy forms — monohydrate has the most evidence.
Frequently Asked Questions
Do I need to load creatine?
No. Loading (20g/day for 5-7 days) saturates muscles faster, but 5g daily reaches the same saturation in ~4 weeks. Loading just causes water retention and GI discomfort for no meaningful long-term advantage.
Does creatine cause hair loss?
One small study from 2009 showed increased DHT with creatine loading. It's never been replicated, and the clinical significance is questionable. If you're genetically predisposed to MPB, monitor — but the evidence for creatine causing hair loss is extremely weak.
Is HMB worth it if I already take creatine?
HMB works through a completely different mechanism (anti-catabolic via mTOR pathway). It's most effective during caloric deficits or for trained athletes. If you're a beginner, creatine alone is sufficient. For advanced lifters in a cut, HMB adds real value.
What about BCAAs?
If you're eating adequate protein (1.6-2.2g/kg bodyweight), BCAAs are a waste of money. They're already in your food. The BCAA industry exists because of marketing, not science.
Get a Personalized Muscle Growth Protocol
These are general recommendations. Your optimal protocol depends on your genetics, bloodwork, current stack, and health history. Let our AI build one specifically for you.