Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Serrapeptase | TUDCA (Tauroursodeoxycholic Acid) | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | 120,000-240,000 SPU (serratiopeptidase units) daily | 250-500mg daily |
| Timing | On empty stomach (critical — food proteins will be digested instead of systemic absorption). 30+ minutes before meals or 2 hours after. | With meals for liver support. Some protocols recommend before meals to prime bile flow. |
| Cycle Duration | Cycle 4-8 weeks on, 2-4 weeks off | Cycle 4-8 weeks for liver support; ongoing at low dose for chronic liver conditions under supervision |
| Evidence Level | moderate_human | Moderate-Strong |
Serrapeptase (serratiopeptidase) is a proteolytic enzyme originally isolated from the gut of the silkworm (Serratia marcescens). It hydrolyzes non-living tissue including fibrin, blood clots, cysts, and arterial plaque while sparing living tissue. It reduces bradykinin and other pain-mediating amines, provides anti-inflammatory effects by reducing neutrophil infiltration, and thins mucus by cleaving glycoprotein structures. It may also enhance antibiotic penetration into biofilms.
120,000-240,000 SPU (serratiopeptidase units) daily
On empty stomach (critical — food proteins will be digested instead of systemic absorption). 30+ minutes before meals or 2 hours after.
Cycle 4-8 weeks on, 2-4 weeks off
TUDCA is a water-soluble bile acid conjugate (taurine + ursodeoxycholic acid) with potent hepatoprotective and cytoprotective properties. It inhibits the mitochondrial pathway of apoptosis by preventing BAX translocation to mitochondria and cytochrome c release. TUDCA reduces endoplasmic reticulum (ER) stress by acting as a chemical chaperone, assisting protein folding and reducing the unfolded protein response (UPR). It protects hepatocytes by stabilizing cell membranes, displacing toxic hydrophobic bile acids (chenodeoxycholic, lithocholic) from biliary epithelium, and promoting choleresis (bile flow). Additionally, it has neuroprotective effects via reduction of ER stress in neurons and modulation of the TGR5 bile acid receptor.
250-500mg daily
With meals for liver support. Some protocols recommend before meals to prime bile flow.
Cycle 4-8 weeks for liver support; ongoing at low dose for chronic liver conditions under supervision
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