Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Serrapeptase | TUDCA | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | 120,000-240,000 SPU (serratiopeptidase units) daily | — |
| Timing | On empty stomach (critical — food proteins will be digested instead of systemic absorption). 30+ minutes before meals or 2 hours after. | — |
| Cycle Duration | Cycle 4-8 weeks on, 2-4 weeks off | — |
| Evidence Level | moderate_human | Moderate |
Serrapeptase (serratiopeptidase) is a proteolytic enzyme originally isolated from the gut of the silkworm (Serratia marcescens). It hydrolyzes non-living tissue including fibrin, blood clots, cysts, and arterial plaque while sparing living tissue. It reduces bradykinin and other pain-mediating amines, provides anti-inflammatory effects by reducing neutrophil infiltration, and thins mucus by cleaving glycoprotein structures. It may also enhance antibiotic penetration into biofilms.
120,000-240,000 SPU (serratiopeptidase units) daily
On empty stomach (critical — food proteins will be digested instead of systemic absorption). 30+ minutes before meals or 2 hours after.
Cycle 4-8 weeks on, 2-4 weeks off
Hydrophilic bile acid that stabilizes hepatocyte membranes, supports bile flow, and reduces endoplasmic reticulum stress. Often used in higher-load liver support and lipid-heavy protocols.
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