Pyrroloquinoline Quinone (PQQ) vs Shilajit (Purified)

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Pyrroloquinoline Quinone (PQQ)Shilajit (Purified)
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerateModerate

Mechanism

Redox cofactor that stimulates mitochondrial biogenesis via PGC-1alpha activation. Potent antioxidant (5000x more efficient than vitamin C in redox cycling). Supports nerve growth factor (NGF) synthesis and protects neurons from oxidative damage.

Contraindications

  • None established at standard doses

Mechanism

Fulvic acid-rich mineral complex that enhances mitochondrial CoQ10 function, increases testosterone (via FSH), and acts as a potent electron carrier in the ETC. Enhances bioavailability of other supplements. Contains dibenzo-alpha-pyrones and fulvic acids.

Contraindications

  • Hemochromatosis
  • Must use purified form — raw shilajit may contain heavy metals

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