Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Pterostilbene | TUDCA (Tauroursodeoxycholic Acid) | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | 250-500mg daily |
| Timing | — | With meals for liver support. Some protocols recommend before meals to prime bile flow. |
| Cycle Duration | — | Cycle 4-8 weeks for liver support; ongoing at low dose for chronic liver conditions under supervision |
| Evidence Level | Moderate | Moderate-Strong |
Dimethylated analog of resveratrol with 4x greater oral bioavailability. Activates SIRT1 and AMPK, reduces oxidative stress, and improves lipid profiles. Superior pharmacokinetics compared to resveratrol due to methyl groups protecting against glucuronidation.
TUDCA is a water-soluble bile acid conjugate (taurine + ursodeoxycholic acid) with potent hepatoprotective and cytoprotective properties. It inhibits the mitochondrial pathway of apoptosis by preventing BAX translocation to mitochondria and cytochrome c release. TUDCA reduces endoplasmic reticulum (ER) stress by acting as a chemical chaperone, assisting protein folding and reducing the unfolded protein response (UPR). It protects hepatocytes by stabilizing cell membranes, displacing toxic hydrophobic bile acids (chenodeoxycholic, lithocholic) from biliary epithelium, and promoting choleresis (bile flow). Additionally, it has neuroprotective effects via reduction of ER stress in neurons and modulation of the TGR5 bile acid receptor.
250-500mg daily
With meals for liver support. Some protocols recommend before meals to prime bile flow.
Cycle 4-8 weeks for liver support; ongoing at low dose for chronic liver conditions under supervision
Take our free assessment to get personalized recommendations based on your health goals, current stack, and biomarkers.
Get Your Free Protocol →or take the assessment →