Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Pterostilbene | Serrapeptase | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | 120,000-240,000 SPU (serratiopeptidase units) daily |
| Timing | — | On empty stomach (critical — food proteins will be digested instead of systemic absorption). 30+ minutes before meals or 2 hours after. |
| Cycle Duration | — | Cycle 4-8 weeks on, 2-4 weeks off |
| Evidence Level | Moderate | moderate_human |
Dimethylated analog of resveratrol with 4x greater oral bioavailability. Activates SIRT1 and AMPK, reduces oxidative stress, and improves lipid profiles. Superior pharmacokinetics compared to resveratrol due to methyl groups protecting against glucuronidation.
Serrapeptase (serratiopeptidase) is a proteolytic enzyme originally isolated from the gut of the silkworm (Serratia marcescens). It hydrolyzes non-living tissue including fibrin, blood clots, cysts, and arterial plaque while sparing living tissue. It reduces bradykinin and other pain-mediating amines, provides anti-inflammatory effects by reducing neutrophil infiltration, and thins mucus by cleaving glycoprotein structures. It may also enhance antibiotic penetration into biofilms.
120,000-240,000 SPU (serratiopeptidase units) daily
On empty stomach (critical — food proteins will be digested instead of systemic absorption). 30+ minutes before meals or 2 hours after.
Cycle 4-8 weeks on, 2-4 weeks off
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