Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Pentadeca Arginate (PDA) | Selank | |
|---|---|---|
| Category | Peptides | Peptides |
| Standard Dose | Research indicates 250-500 mcg administered 1-2 times daily via subcutaneous injection. | Research indicates 250-500 mcg daily via intranasal administration (0.15% solution, 2-3 drops per nostril). |
| Timing | Administer on an empty stomach. Inject near site of injury for localized effect. | Can be dosed morning through evening. Unlike Semax, Selank is calming and can be used at night. |
| Cycle Duration | 4-12 weeks depending on therapeutic target. | 14-21 day cycles with equal rest periods. |
| Evidence Level | animal_plus_anecdotal | moderate_human |
Pentadeca Arginate is a synthetic 15-amino acid peptide utilizing an arginate salt formulation of the BPC-157 sequence, designed to enhance nitric oxide production and promote angiogenesis. It stimulates collagen synthesis, enhances tissue repair through increased tensile strength, reduces inflammation via modulation of inflammatory cytokines, and accelerates cellular proliferation in tendon fibroblasts. The arginate salt form provides superior stability and bioavailability compared to traditional acetate formulations.
Research indicates 250-500 mcg administered 1-2 times daily via subcutaneous injection.
Administer on an empty stomach. Inject near site of injury for localized effect.
4-12 weeks depending on therapeutic target.
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin (from IgG heavy chain) with a Pro-Gly-Pro extension for metabolic stability. It allosterically modulates GABA-A receptors, enhancing GABA binding and GABAergic neurotransmission. Selank modifies mRNA levels of 84 genes involved in GABAergic neurotransmission in the frontal cortex, enhances enkephalinase inhibition (increasing endogenous enkephalin levels), and modulates serotonergic and noradrenergic systems to produce anxiolytic and nootropic effects.
Research indicates 250-500 mcg daily via intranasal administration (0.15% solution, 2-3 drops per nostril).
Can be dosed morning through evening. Unlike Semax, Selank is calming and can be used at night.
14-21 day cycles with equal rest periods.
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