Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| CJC-1295 (with DAC) | Selank | |
|---|---|---|
| Category | Peptides | Peptides |
| Standard Dose | Research indicates 2 mg administered once weekly via subcutaneous injection. | Research indicates 250-500 mcg daily via intranasal administration (0.15% solution, 2-3 drops per nostril). |
| Timing | Evening administration preferred (aligns with natural GH pulsatility). Inject on an empty stomach — food (especially carbohydrates) blunts GH release. | Can be dosed morning through evening. Unlike Semax, Selank is calming and can be used at night. |
| Cycle Duration | 12-24 week cycles with 4-8 week breaks between cycles. | 14-21 day cycles with equal rest periods. |
| Evidence Level | moderate_human | moderate_human |
CJC-1295 with DAC (Drug Affinity Complex) is a synthetic 30-amino acid GHRH analog with four amino acid substitutions rendering it resistant to DPP-IV proteolytic inactivation. The DAC moiety covalently binds to endogenous serum albumin via a disulfide bond after injection, extending half-life to 5.8-8.1 days. It stimulates pulsatile GH release from anterior pituitary somatotrophs through GHRH receptor activation, producing dose-dependent 2-10 fold increases in plasma GH for 6+ days and 1.5-3 fold IGF-1 elevations for 9-11 days per injection.
Research indicates 2 mg administered once weekly via subcutaneous injection.
Evening administration preferred (aligns with natural GH pulsatility). Inject on an empty stomach — food (especially carbohydrates) blunts GH release.
12-24 week cycles with 4-8 week breaks between cycles.
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin (from IgG heavy chain) with a Pro-Gly-Pro extension for metabolic stability. It allosterically modulates GABA-A receptors, enhancing GABA binding and GABAergic neurotransmission. Selank modifies mRNA levels of 84 genes involved in GABAergic neurotransmission in the frontal cortex, enhances enkephalinase inhibition (increasing endogenous enkephalin levels), and modulates serotonergic and noradrenergic systems to produce anxiolytic and nootropic effects.
Research indicates 250-500 mcg daily via intranasal administration (0.15% solution, 2-3 drops per nostril).
Can be dosed morning through evening. Unlike Semax, Selank is calming and can be used at night.
14-21 day cycles with equal rest periods.
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