Peptides
Evidence: moderate_human
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin (from IgG heavy chain) with a Pro-Gly-Pro extension for metabolic stability. It allosterically modulates GABA-A receptors, enhancing GABA binding and GABAergic neurotransmission. Selank modifies mRNA levels of 84 genes involved in GABAergic neurotransmission in the frontal cortex, enhances enkephalinase inhibition (increasing endogenous enkephalin levels), and modulates serotonergic and noradrenergic systems to produce anxiolytic and nootropic effects.
Standard: Research indicates 250-500 mcg daily via intranasal administration (0.15% solution, 2-3 drops per nostril).
Maintenance: Research indicates 250 mcg daily intranasally.
Administration: intranasalsubcutaneous
Timing: Can be dosed morning through evening. Unlike Semax, Selank is calming and can be used at night.
Duration: 14-21 day cycles with equal rest periods.
Selank is approved in Russia as an anxiolytic and nootropic. Its dual mechanism — GABAergic anxiolysis plus tuftsin-derived immunomodulation — makes it unique among peptide nootropics. It enhances diazepam's anxiolytic effects in research models, suggesting true GABAergic activity. The cognitive stack (Semax + Selank) is widely used in the biohacking community with consistent reports of reduced anxiety plus enhanced focus. Selank is better tolerated than Semax for anxiety-prone individuals.
Russian pharmaceutical-grade (approved in Russia). Research-grade suppliers internationally. Pre-made nasal spray preferred.
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