Palmitoylethanolamide (PEA) vs Shilajit (Purified)

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Palmitoylethanolamide (PEA)Shilajit (Purified)
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelStrongModerate

Mechanism

Endocannabinoid-like lipid that activates PPAR-alpha and indirectly enhances endocannabinoid tone. Potent anti-inflammatory and analgesic without acting directly on CB1/CB2. Reduces mast cell activation, neuroinflammation, and chronic pain.

Contraindications

  • None established at standard doses

Mechanism

Fulvic acid-rich mineral complex that enhances mitochondrial CoQ10 function, increases testosterone (via FSH), and acts as a potent electron carrier in the ETC. Enhances bioavailability of other supplements. Contains dibenzo-alpha-pyrones and fulvic acids.

Contraindications

  • Hemochromatosis
  • Must use purified form — raw shilajit may contain heavy metals

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