Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Nattokinase | Phosphatidylserine (PS) | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | 2000-4000 FU (fibrinolytic units) daily, equivalent to 100-200mg | — |
| Timing | On empty stomach, between meals or before bed. Morning and evening split dosing for 24-hour fibrinolytic coverage. | — |
| Cycle Duration | ongoing | — |
| Evidence Level | moderate_human | Moderate-Strong |
Nattokinase is a fibrinolytic serine protease extracted from natto (fermented soybeans). It directly degrades fibrin (the structural protein of blood clots) through four mechanisms: direct fibrinolysis, enhancement of endogenous tPA (tissue plasminogen activator) production, conversion of prourokinase to urokinase, and degradation of PAI-1 (plasminogen activator inhibitor-1). It also reduces blood viscosity and may inhibit ACE (angiotensin-converting enzyme), providing mild antihypertensive effects.
2000-4000 FU (fibrinolytic units) daily, equivalent to 100-200mg
On empty stomach, between meals or before bed. Morning and evening split dosing for 24-hour fibrinolytic coverage.
ongoing
Phospholipid concentrated in brain cell membranes. Supports neurotransmitter production (acetylcholine, dopamine), cortisol regulation, and membrane fluidity. Improves cognitive function, reduces exercise-induced cortisol, and supports HPA axis recovery.
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