Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| NAC (N-Acetyl Cysteine) | Pterostilbene | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | 600-1200mg daily | — |
| Timing | On empty stomach for best absorption, 30 min before meals. Split doses if >600mg. | — |
| Cycle Duration | Cycle 8 weeks on, 2 weeks off (to avoid potential downregulation of endogenous GSH production) | — |
| Evidence Level | strong_human | Moderate |
NAC is a precursor to L-cysteine, the rate-limiting substrate for glutathione (GSH) synthesis via glutamate-cysteine ligase. It directly replenishes intracellular GSH, the master endogenous antioxidant. NAC also modulates glutamatergic neurotransmission by stimulating the cystine-glutamate antiporter (system Xc-), influencing extrasynaptic glutamate levels. Additionally, it acts as a mucolytic by cleaving disulfide bonds in mucus glycoproteins.
600-1200mg daily
On empty stomach for best absorption, 30 min before meals. Split doses if >600mg.
Cycle 8 weeks on, 2 weeks off (to avoid potential downregulation of endogenous GSH production)
Dimethylated analog of resveratrol with 4x greater oral bioavailability. Activates SIRT1 and AMPK, reduces oxidative stress, and improves lipid profiles. Superior pharmacokinetics compared to resveratrol due to methyl groups protecting against glucuronidation.
Take our free assessment to get personalized recommendations based on your health goals, current stack, and biomarkers.
Get Your Free Protocol →or take the assessment →