Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Methylene Blue (Pharmaceutical Grade) | Selegiline | |
|---|---|---|
| Category | Pharmaceuticals | Pharmaceuticals |
| Standard Dose | — | — |
| Timing | — | — |
| Cycle Duration | — | — |
| Evidence Level | Moderate (cognitive), Strong (mitochondrial mechanism) | Strong |
Alternative electron carrier in the mitochondrial electron transport chain. Bypasses Complex I and III dysfunction by shuttling electrons directly to Complex IV (cytochrome c oxidase). Also inhibits tau aggregation, monoamine oxidase, and nitric oxide synthase. Hormetic — low doses are beneficial, high doses are toxic.
Selective MAO-B inhibitor that raises dopaminergic tone at lower doses and is used clinically in Parkinson's disease and select mood protocols.
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