Bupropion SR vs Selegiline

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Bupropion SRSelegiline
CategoryPharmaceuticalsPharmaceuticals
Standard Dose
Timing
Cycle Duration
Evidence LevelStrongStrong
A

Bupropion SR

Pharmaceuticals

Mechanism

Norepinephrine-dopamine reuptake inhibitor used clinically for mood, motivation, and smoking cessation.

Contraindications

  • Seizure disorders
  • Eating disorders
B

Selegiline

Pharmaceuticals

Mechanism

Selective MAO-B inhibitor that raises dopaminergic tone at lower doses and is used clinically in Parkinson's disease and select mood protocols.

Contraindications

  • Do not combine casually with SSRIs or stimulants

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