Pharmaceuticals

Methylene Blue (Pharmaceutical Grade)

Evidence: Moderate (cognitive), Strong (mitochondrial mechanism)

Mechanism of Action

Alternative electron carrier in the mitochondrial electron transport chain. Bypasses Complex I and III dysfunction by shuttling electrons directly to Complex IV (cytochrome c oxidase). Also inhibits tau aggregation, monoamine oxidase, and nitric oxide synthase. Hormetic — low doses are beneficial, high doses are toxic.

Interactions

  • DANGEROUS with serotonergic drugs (SSRIs, MAOIs, SNRIs) — serotonin syndrome risk
  • Avoid with other MAOIs

Contraindications

  • G6PD deficiency (hemolytic anemia)
  • Concurrent serotonergic medication
  • Renal impairment
  • Pregnancy

Key Papers

  • Rojas et al. 2012 - Methylene blue provides behavioral and metabolic neuroprotection (Neuroscience)
Disclaimer: This information is for educational purposes only and is not medical advice. BioAccelera Labs does not diagnose, treat, or prescribe. Consult a licensed healthcare provider before using any compound.

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