Metformin XR vs Selegiline

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Metformin XRSelegiline
CategoryPharmaceuticalsPharmaceuticals
Standard Dose
Timing
Cycle Duration
Evidence LevelStrongStrong
A

Metformin XR

Pharmaceuticals

Mechanism

AMPK-activating insulin sensitizer that reduces hepatic glucose output and improves glycemic control. Also used in longevity-oriented discussion due metabolic effects.

Contraindications

  • Severe renal impairment
  • Acute illness with lactic acidosis risk
B

Selegiline

Pharmaceuticals

Mechanism

Selective MAO-B inhibitor that raises dopaminergic tone at lower doses and is used clinically in Parkinson's disease and select mood protocols.

Contraindications

  • Do not combine casually with SSRIs or stimulants

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