Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Canagliflozin | Metformin XR | |
|---|---|---|
| Category | Pharmaceuticals | Pharmaceuticals |
| Standard Dose | — | — |
| Timing | — | — |
| Cycle Duration | — | — |
| Evidence Level | Moderate (longevity), Strong (cardiorenal) | Strong |
SGLT2 inhibitor originally developed for type 2 diabetes. Blocks glucose reabsorption in kidneys, creating a mild glucose deficit that activates AMPK and mimics caloric restriction. Extended lifespan in male mice in the ITP.
AMPK-activating insulin sensitizer that reduces hepatic glucose output and improves glycemic control. Also used in longevity-oriented discussion due metabolic effects.
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