Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Glycine + NAC (GlyNAC) | Sulforaphane (from Broccoli Sprout Extract) | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | — |
| Timing | — | — |
| Cycle Duration | — | — |
| Evidence Level | Strong | Strong |
Combination that restores glutathione synthesis. Age-related glutathione deficiency is driven by glycine and cysteine precursor depletion, not enzyme dysfunction. GlyNAC corrects oxidative stress, mitochondrial dysfunction, inflammation, and insulin resistance in older adults.
Isothiocyanate that activates Nrf2 — the master regulator of antioxidant defense. Upregulates glutathione synthesis, phase II detoxification enzymes, and heat shock proteins. Also inhibits HDAC (epigenetic modifier) and NF-kB (anti-inflammatory).
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