Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Apigenin | Glycine + NAC (GlyNAC) | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | — |
| Timing | — | — |
| Cycle Duration | — | — |
| Evidence Level | Moderate | Strong |
Flavonoid (found in chamomile, parsley) that inhibits CD38, the primary NAD+-consuming enzyme. Also a potent aromatase inhibitor and anxiolytic via GABA-A modulation. Supports NAD+ levels, reduces estrogen conversion, and improves sleep quality.
Combination that restores glutathione synthesis. Age-related glutathione deficiency is driven by glycine and cysteine precursor depletion, not enzyme dysfunction. GlyNAC corrects oxidative stress, mitochondrial dysfunction, inflammation, and insulin resistance in older adults.
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