Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Fadogia Agrestis | Maca Root (Gelatinized) | |
|---|---|---|
| Category | Adaptogens | Adaptogens |
| Standard Dose | 400-600mg daily | 1500-3000mg gelatinized maca daily |
| Timing | Morning with food. | Morning with breakfast. Can be added to smoothies. |
| Cycle Duration | Cycle 4-8 weeks on, 2-4 weeks off (limited long-term safety data) | Cycle 12 weeks on, 4 weeks off, or ongoing |
| Evidence Level | animal_plus_anecdotal | moderate_human |
Fadogia agrestis stem extract contains saponins and alkaloids that appear to increase luteinizing hormone (LH) release from the anterior pituitary, stimulating Leydig cell testosterone production. Animal studies suggest it may also have direct effects on testicular steroidogenic enzymes and may increase testicular weight. The saponin content may modulate gonadotropin-releasing hormone (GnRH) pulse frequency. The aphrodisiac effects are likely mediated through increased testosterone and possibly direct effects on dopaminergic and nitrergic pathways.
400-600mg daily
Morning with food.
Cycle 4-8 weeks on, 2-4 weeks off (limited long-term safety data)
Maca (Lepidium meyenii) contains unique macamides and macaenes (fatty acid derivatives), glucosinolates, and alkaloids. Unlike most adaptogens, maca does not directly affect testosterone, estrogen, or cortisol levels in blood. Instead, it appears to work as a 'hormonal normalizer' by acting on the hypothalamic-pituitary axis, modulating GnRH pulsatility and improving receptor sensitivity. Macamides interact with the endocannabinoid system (FAAH inhibition) and may modulate GABA and opioid pathways. Maca improves sexual function and desire through mechanisms independent of direct hormone elevation — likely central nervous system pathways.
1500-3000mg gelatinized maca daily
Morning with breakfast. Can be added to smoothies.
Cycle 12 weeks on, 4 weeks off, or ongoing
Take our free assessment to get personalized recommendations based on your health goals, current stack, and biomarkers.
Get Your Free Protocol →or take the assessment →