Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Diosmin + Hesperidin | Omega-3 (EPA/DHA) | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | 2-4g combined EPA/DHA daily (targeting 2:1 EPA:DHA ratio for inflammation; 1:1 for cognitive) |
| Timing | — | With meals containing fat for absorption. Split dose AM/PM. |
| Cycle Duration | — | ongoing |
| Evidence Level | Strong (venous insufficiency — prescription in EU) | strong_human |
Micronized flavonoid fraction that strengthens venous tone, reduces capillary permeability, and improves lymphatic drainage. Inhibits prostaglandin and thromboxane synthesis. Used as prescription venotonic in Europe for chronic venous insufficiency and hemorrhoids.
EPA and DHA incorporate into cell membrane phospholipids, modulating membrane fluidity and lipid raft signaling. EPA competitively inhibits arachidonic acid conversion via COX-2 and 5-LOX, reducing pro-inflammatory eicosanoids (PGE2, LTB4) while generating anti-inflammatory resolvins and protectins. DHA is critical for neuronal membrane integrity, modulating BDNF expression and synaptic plasticity via Nrf2 and NF-kB pathways.
2-4g combined EPA/DHA daily (targeting 2:1 EPA:DHA ratio for inflammation; 1:1 for cognitive)
With meals containing fat for absorption. Split dose AM/PM.
ongoing
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