Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Apigenin | Diosmin + Hesperidin | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | — |
| Timing | — | — |
| Cycle Duration | — | — |
| Evidence Level | Moderate | Strong (venous insufficiency — prescription in EU) |
Flavonoid (found in chamomile, parsley) that inhibits CD38, the primary NAD+-consuming enzyme. Also a potent aromatase inhibitor and anxiolytic via GABA-A modulation. Supports NAD+ levels, reduces estrogen conversion, and improves sleep quality.
Micronized flavonoid fraction that strengthens venous tone, reduces capillary permeability, and improves lymphatic drainage. Inhibits prostaglandin and thromboxane synthesis. Used as prescription venotonic in Europe for chronic venous insufficiency and hemorrhoids.
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