Supplements

Omega-3 (EPA/DHA)

Evidence: strong_human

Mechanism of Action

EPA and DHA incorporate into cell membrane phospholipids, modulating membrane fluidity and lipid raft signaling. EPA competitively inhibits arachidonic acid conversion via COX-2 and 5-LOX, reducing pro-inflammatory eicosanoids (PGE2, LTB4) while generating anti-inflammatory resolvins and protectins. DHA is critical for neuronal membrane integrity, modulating BDNF expression and synaptic plasticity via Nrf2 and NF-kB pathways.

Dosing Protocol

Standard: 2-4g combined EPA/DHA daily (targeting 2:1 EPA:DHA ratio for inflammation; 1:1 for cognitive)

Loading: 4-6g/day for 4 weeks

Maintenance: 2-3g/day

Administration: oral

Timing: With meals containing fat for absorption. Split dose AM/PM.

Duration: ongoing

Notes

Omega-3 Index blood test target: 8-12%. EPA:DHA ratio matters for indication. Higher EPA for inflammation/mood; higher DHA for cognition/neuroprotection. Rancidity is a major quality concern — check peroxide and anisidine values.

Stacking

  • Vitamin D3
  • Vitamin E (mixed tocopherols)
  • Astaxanthin
  • Curcumin

Interactions

  • Warfarin/anticoagulants [HIGH] — Additive antiplatelet effect; monitor INR closely above 3g/day
  • Aspirin [MEDIUM] — Synergistic antiplatelet; may increase bleeding risk at high doses
  • Blood pressure medications [LOW] — Mild additive hypotensive effect

Contraindications

  • Active bleeding disorders
  • Scheduled surgery (discontinue 2 weeks prior)
  • Fish/shellfish allergy (use algal-derived)

Side Effects

  • Fishy burps/aftertaste
  • Mild GI upset
  • Loose stools at high doses
  • Potential increased LDL in some individuals

Key Papers

  • 10.1016/S0140-6736(18)31356-X
  • 10.1001/jama.2020.22258
  • 10.1161/CIRCULATIONAHA.119.044584

Source Quality

Triglyceride or re-esterified triglyceride form preferred over ethyl ester. IFOS 5-star certified. Molecular distillation for purity. Store refrigerated. Nordic Naturals, Carlson, or pharmaceutical-grade (Lovaza/Vascepa).

Disclaimer: This information is for educational purposes only and is not medical advice. BioAccelera Labs does not diagnose, treat, or prescribe. Consult a licensed healthcare provider before using any compound.

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