Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Citrus Bergamot Extract | Urolithin A | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | — |
| Timing | — | — |
| Cycle Duration | — | — |
| Evidence Level | Moderate-Strong | Moderate-Strong |
Contains brutieridin and melitidin — statin-like HMG-CoA reductase inhibitors from bergamot orange. Activates AMPK, improves lipid profiles (reduces LDL, increases HDL), and has antioxidant effects. Supports cardiovascular and metabolic health.
Gut metabolite of ellagitannins that activates mitophagy — selective clearance of damaged mitochondria. Improves mitochondrial function, muscle endurance, and cellular energy production. Only ~40% of population can produce it endogenously.
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