Citrus Bergamot Extract vs TUDCA

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Citrus Bergamot ExtractTUDCA
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerate-StrongModerate

Mechanism

Contains brutieridin and melitidin — statin-like HMG-CoA reductase inhibitors from bergamot orange. Activates AMPK, improves lipid profiles (reduces LDL, increases HDL), and has antioxidant effects. Supports cardiovascular and metabolic health.

Contraindications

  • Rhabdomyolysis risk if combined with high-dose statins without monitoring
B

TUDCA

Supplements

Mechanism

Hydrophilic bile acid that stabilizes hepatocyte membranes, supports bile flow, and reduces endoplasmic reticulum stress. Often used in higher-load liver support and lipid-heavy protocols.

Contraindications

  • Caution with active gallbladder obstruction

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