Citrus Bergamot Extract vs Glucoraphanin (Broccoli Seed Extract)

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Citrus Bergamot ExtractGlucoraphanin (Broccoli Seed Extract)
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerate-StrongModerate-Strong

Mechanism

Contains brutieridin and melitidin — statin-like HMG-CoA reductase inhibitors from bergamot orange. Activates AMPK, improves lipid profiles (reduces LDL, increases HDL), and has antioxidant effects. Supports cardiovascular and metabolic health.

Contraindications

  • Rhabdomyolysis risk if combined with high-dose statins without monitoring

Mechanism

Stable precursor to sulforaphane. Requires myrosinase enzyme (from gut bacteria or co-administered) for conversion. Provides sustained sulforaphane release compared to direct supplementation. Activates Nrf2 pathway for antioxidant and detoxification gene expression.

Contraindications

  • Thyroid conditions (goitrogen at very high doses)

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