Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Calcium Alpha-Ketoglutarate (Ca-AKG) | Serrapeptase | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | 120,000-240,000 SPU (serratiopeptidase units) daily |
| Timing | — | On empty stomach (critical — food proteins will be digested instead of systemic absorption). 30+ minutes before meals or 2 hours after. |
| Cycle Duration | — | Cycle 4-8 weeks on, 2-4 weeks off |
| Evidence Level | Moderate (healthspan), Emerging (human longevity) | moderate_human |
AKG is a TCA cycle intermediate that declines with age. Supplementation reduces inflammatory cytokines, improves stem cell function, and extends healthspan in mice. Calcium salt form provides sustained release. Also supports collagen synthesis and reduces frailty markers.
Serrapeptase (serratiopeptidase) is a proteolytic enzyme originally isolated from the gut of the silkworm (Serratia marcescens). It hydrolyzes non-living tissue including fibrin, blood clots, cysts, and arterial plaque while sparing living tissue. It reduces bradykinin and other pain-mediating amines, provides anti-inflammatory effects by reducing neutrophil infiltration, and thins mucus by cleaving glycoprotein structures. It may also enhance antibiotic penetration into biofilms.
120,000-240,000 SPU (serratiopeptidase units) daily
On empty stomach (critical — food proteins will be digested instead of systemic absorption). 30+ minutes before meals or 2 hours after.
Cycle 4-8 weeks on, 2-4 weeks off
Take our free assessment to get personalized recommendations based on your health goals, current stack, and biomarkers.
Get Your Free Protocol →or take the assessment →