Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Calcium Alpha-Ketoglutarate (Ca-AKG) | Omega-3 (EPA/DHA) | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | 2-4g combined EPA/DHA daily (targeting 2:1 EPA:DHA ratio for inflammation; 1:1 for cognitive) |
| Timing | — | With meals containing fat for absorption. Split dose AM/PM. |
| Cycle Duration | — | ongoing |
| Evidence Level | Moderate (healthspan), Emerging (human longevity) | strong_human |
AKG is a TCA cycle intermediate that declines with age. Supplementation reduces inflammatory cytokines, improves stem cell function, and extends healthspan in mice. Calcium salt form provides sustained release. Also supports collagen synthesis and reduces frailty markers.
EPA and DHA incorporate into cell membrane phospholipids, modulating membrane fluidity and lipid raft signaling. EPA competitively inhibits arachidonic acid conversion via COX-2 and 5-LOX, reducing pro-inflammatory eicosanoids (PGE2, LTB4) while generating anti-inflammatory resolvins and protectins. DHA is critical for neuronal membrane integrity, modulating BDNF expression and synaptic plasticity via Nrf2 and NF-kB pathways.
2-4g combined EPA/DHA daily (targeting 2:1 EPA:DHA ratio for inflammation; 1:1 for cognitive)
With meals containing fat for absorption. Split dose AM/PM.
ongoing
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