Bromelain vs Omega-3 (EPA/DHA)

Mechanism

Proteolytic enzyme complex from pineapple stems. Anti-inflammatory via modulation of prostaglandin synthesis, fibrinolytic, and anti-edematous. Degrades fibrin and reduces blood viscosity. Enhances absorption of other supplements (particularly quercetin and curcumin).

Contraindications

• Pineapple allergy
• Pre-surgery (bleeding risk)
• Active bleeding

Mechanism

EPA and DHA incorporate into cell membrane phospholipids, modulating membrane fluidity and lipid raft signaling. EPA competitively inhibits arachidonic acid conversion via COX-2 and 5-LOX, reducing pro-inflammatory eicosanoids (PGE2, LTB4) while generating anti-inflammatory resolvins and protectins. DHA is critical for neuronal membrane integrity, modulating BDNF expression and synaptic plasticity via Nrf2 and NF-kB pathways.

Standard Dosing

2-4g combined EPA/DHA daily (targeting 2:1 EPA:DHA ratio for inflammation; 1:1 for cognitive)

Timing

With meals containing fat for absorption. Split dose AM/PM.

Cycle Duration

ongoing

Side Effects

• Fishy burps/aftertaste
• Mild GI upset
• Loose stools at high doses
• Potential increased LDL in some individuals

Contraindications

• Active bleeding disorders
• Scheduled surgery (discontinue 2 weeks prior)
• Fish/shellfish allergy (use algal-derived)

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