Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Black Seed Oil (Nigella sativa) | Serrapeptase | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | 120,000-240,000 SPU (serratiopeptidase units) daily |
| Timing | — | On empty stomach (critical — food proteins will be digested instead of systemic absorption). 30+ minutes before meals or 2 hours after. |
| Cycle Duration | — | Cycle 4-8 weeks on, 2-4 weeks off |
| Evidence Level | Moderate | moderate_human |
Contains thymoquinone as active compound. Anti-inflammatory via NF-kB inhibition, immunomodulatory, hepatoprotective. Improves blood sugar regulation via AMPK activation. Supports respiratory health and has antimicrobial properties.
Serrapeptase (serratiopeptidase) is a proteolytic enzyme originally isolated from the gut of the silkworm (Serratia marcescens). It hydrolyzes non-living tissue including fibrin, blood clots, cysts, and arterial plaque while sparing living tissue. It reduces bradykinin and other pain-mediating amines, provides anti-inflammatory effects by reducing neutrophil infiltration, and thins mucus by cleaving glycoprotein structures. It may also enhance antibiotic penetration into biofilms.
120,000-240,000 SPU (serratiopeptidase units) daily
On empty stomach (critical — food proteins will be digested instead of systemic absorption). 30+ minutes before meals or 2 hours after.
Cycle 4-8 weeks on, 2-4 weeks off
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