Apigenin vs Black Seed Oil (Nigella sativa)

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

ApigeninBlack Seed Oil (Nigella sativa)
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerateModerate
A

Apigenin

Supplements

Mechanism

Flavonoid (found in chamomile, parsley) that inhibits CD38, the primary NAD+-consuming enzyme. Also a potent aromatase inhibitor and anxiolytic via GABA-A modulation. Supports NAD+ levels, reduces estrogen conversion, and improves sleep quality.

Contraindications

  • Caution in pregnancy (uterotonic potential at high doses)

Mechanism

Contains thymoquinone as active compound. Anti-inflammatory via NF-kB inhibition, immunomodulatory, hepatoprotective. Improves blood sugar regulation via AMPK activation. Supports respiratory health and has antimicrobial properties.

Contraindications

  • Pregnancy (uterotonic)
  • Pre-surgery (bleeding risk)

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