Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.
| Black Seed Oil (Nigella sativa) | Omega-3 (EPA/DHA) | |
|---|---|---|
| Category | Supplements | Supplements |
| Standard Dose | — | 2-4g combined EPA/DHA daily (targeting 2:1 EPA:DHA ratio for inflammation; 1:1 for cognitive) |
| Timing | — | With meals containing fat for absorption. Split dose AM/PM. |
| Cycle Duration | — | ongoing |
| Evidence Level | Moderate | strong_human |
Contains thymoquinone as active compound. Anti-inflammatory via NF-kB inhibition, immunomodulatory, hepatoprotective. Improves blood sugar regulation via AMPK activation. Supports respiratory health and has antimicrobial properties.
EPA and DHA incorporate into cell membrane phospholipids, modulating membrane fluidity and lipid raft signaling. EPA competitively inhibits arachidonic acid conversion via COX-2 and 5-LOX, reducing pro-inflammatory eicosanoids (PGE2, LTB4) while generating anti-inflammatory resolvins and protectins. DHA is critical for neuronal membrane integrity, modulating BDNF expression and synaptic plasticity via Nrf2 and NF-kB pathways.
2-4g combined EPA/DHA daily (targeting 2:1 EPA:DHA ratio for inflammation; 1:1 for cognitive)
With meals containing fat for absorption. Split dose AM/PM.
ongoing
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