Black Seed Oil (Nigella sativa) vs Citrus Bergamot Extract

Side-by-side comparison of mechanisms, dosing, interactions, and stacking potential.

Black Seed Oil (Nigella sativa)Citrus Bergamot Extract
CategorySupplementsSupplements
Standard Dose
Timing
Cycle Duration
Evidence LevelModerateModerate-Strong

Mechanism

Contains thymoquinone as active compound. Anti-inflammatory via NF-kB inhibition, immunomodulatory, hepatoprotective. Improves blood sugar regulation via AMPK activation. Supports respiratory health and has antimicrobial properties.

Contraindications

  • Pregnancy (uterotonic)
  • Pre-surgery (bleeding risk)

Mechanism

Contains brutieridin and melitidin — statin-like HMG-CoA reductase inhibitors from bergamot orange. Activates AMPK, improves lipid profiles (reduces LDL, increases HDL), and has antioxidant effects. Supports cardiovascular and metabolic health.

Contraindications

  • Rhabdomyolysis risk if combined with high-dose statins without monitoring

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