Evidence-Based Compounds That Actually Support Fat Loss
No supplement will make you lose fat without a caloric deficit. Full stop. But once your diet and training are dialed in, certain compounds can meaningfully accelerate fat oxidation, improve insulin sensitivity, and preserve lean mass during a cut. Here's what actually works.
Top Compounds
The BioAccelera Fat Loss Stack
⏰ Morning fasted or pre-workout
- Caffeine 200mg + L-Carnitine (ALCAR) 2g pre-workout
- Green tea extract 500mg (standardized to 50% EGCG)
- Berberine 500mg 2-3x daily with meals
- Yohimbine 2.5-5mg fasted (contraindicated with anxiety)
💡 Berberine is essentially nature's metformin — it activates AMPK and dramatically improves insulin sensitivity. Take it WITH meals containing carbs. Yohimbine only works in a fasted state and can cause anxiety in sensitive individuals. Start low.
Frequently Asked Questions
Do fat burners work?
Most commercial fat burners are caffeine pills with pixie-dusted extras. Individual compounds at clinical doses (caffeine, EGCG, yohimbine, L-carnitine) have evidence. Proprietary blends are almost always underdosed garbage.
How does berberine compare to metformin?
They activate similar pathways (AMPK) and show comparable effects on blood glucose and insulin sensitivity in head-to-head trials. Berberine is OTC and well-tolerated. It's not identical to metformin, but for metabolic health and fat loss support, it's the closest natural equivalent.
Should I take L-carnitine orally or inject?
Oral L-carnitine has poor bioavailability (~15%). Injectable L-carnitine is 100% bioavailable. If you're serious about using carnitine for fat oxidation, injections are significantly more effective. Oral ALCAR is better for cognitive benefits since it crosses the BBB.
Is yohimbine dangerous?
At recommended doses (0.2mg/kg bodyweight), it's generally safe for healthy individuals. But it raises blood pressure, can cause severe anxiety, and interacts with many medications. Never combine with MAOIs. Start at 2.5mg and assess tolerance. Skip it entirely if you have anxiety disorders.
Get a Personalized Fat Loss Protocol
These are general recommendations. Your optimal protocol depends on your genetics, bloodwork, current stack, and health history. Let our AI build one specifically for you.