Nootropics
Evidence: moderate_human
Potently stimulates high-affinity choline uptake (HACU) in hippocampal synaptosomes, the rate-limiting step in acetylcholine synthesis. This profoundly enhances cholinergic neurotransmission without direct receptor agonism. Approximately 10-30x more potent than piracetam on a per-milligram basis. Does not significantly affect other neurotransmitter systems, making it a highly targeted cholinergic enhancer.
Standard: 400-1200 mg/day divided into 2-3 doses
Maintenance: 600 mg twice daily
Administration: oral
Timing: With fat-containing meals (fat-soluble). Morning and early afternoon dosing preferred.
Duration: Cycles of 8-12 weeks on, 4 weeks off
Often described as the most focused and 'clean' racetam — users report enhanced logical thinking and working memory without mood alteration. Some users report emotional flattening, which can be either a benefit or drawback depending on context. Must co-supplement with choline. The taste is exceptionally bitter, making encapsulation essential.
Fat-soluble with an intensely bitter taste. Capsules strongly preferred over powder. Source with CoA from established nootropic vendors. Italian pharmaceutical-grade (Pramistar) is the gold standard if obtainable.
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